Arizona Health Sciences

Cancer-induced bone pain: Mechanisms and models.

TitleCancer-induced bone pain: Mechanisms and models.
Publication TypeJournal Article
Year of Publication2013
AuthorsLozano-Ondoua AN, Symons-Liguori AM, Vanderah TW
JournalNeurosci Lett
Volume557 Pt A
Pagination52-9
Date Published2013 Dec 17
ISSN1872-7972
KeywordsAcid Sensing Ion Channels, Animals, Bone Neoplasms, Cytokines, Disease Models, Animal, Humans, Mice, Nerve Growth Factors, Oxidative Stress, Pain, Rats
Abstract

Cancerous cells can originate in a number of different tissues such as prostate, breast and lung, but often go undetected and are non-painful. Many types of cancers have a propensity to metastasize to the bone microenvironment first. Tumor burden within the bone causes excruciating breakthrough pain with properties of ongoing pain that is inadequately managed with current analgesics. Part of this failure is due to the poor understanding of the etiology of cancer pain. Animal models of cancer-induced bone pain (CIBP) have revealed that the neurochemistry of cancer has features distinctive from other chronic pain states. For example, preclinical models of metastatic cancer often result in the positive modulation of neurotrophins, such as NGF and BDNF, that can lead to nociceptive sensitization. Preclinical cancer models also demonstrate nociceptive neuronal expression of acid-sensing receptors, such as ASIC1 and TRPV1, which respond to cancer-induced acidity within the bone. CIBP is correlated with a significant increase in pro-inflammatory mediators acting peripherally and centrally, contributing to neuronal hypersensitive states. Finally, cancer cells generate high levels of oxidative molecules that are thought to increase extracellular glutamate concentrations, thus activating primary afferent neurons. Knowledge of the unique neuro-molecular profile of cancer pain will ultimately lead to the development of novel and superior therapeutics for CIBP.

DOI10.1016/j.neulet.2013.08.003
Alternate JournalNeurosci. Lett.
PubMed ID24076008
Grant ListR01 CA142115 / CA / NCI NIH HHS / United States
Faculty Member Reference: 
Todd Vanderah, PhD