Arizona Health Sciences

Emerging Roles of Transforming Growth Factor β Signaling in Diabetic Retinopathy.

TitleEmerging Roles of Transforming Growth Factor β Signaling in Diabetic Retinopathy.
Publication TypeJournal Article
Year of Publication2017
AuthorsWheeler SE, Lee NY
JournalJ Cell Physiol
Volume232
Issue3
Pagination486-489
Date Published2017 Mar
ISSN1097-4652
KeywordsAnimals, Diabetic Retinopathy, Disease Progression, Humans, Models, Biological, Signal Transduction, Transforming Growth Factor beta
Abstract

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus affecting about one third of diabetic adults. Despite its prevalence, treatment options are limited and often implemented only in the later stages of the disease. To date, the pathogenesis of DR has been extensively characterized in the context of elevated glucose, insulin, and VEGF signaling, although a growing number of other growth factors and molecules, including transforming growth factor β (TGF-β) are being recognized as important contributors and/or therapeutic targets. Here, we review the complex roles of TGF-β signaling in DR pathogenesis and progression. J. Cell. Physiol. 232: 486-489, 2017. © 2016 Wiley Periodicals, Inc.

DOI10.1002/jcp.25506
Alternate JournalJ. Cell. Physiol.
PubMed ID27472503
Faculty Member Reference: 
Nam Lee, Ph.D.