Diagnosis of infection by next-generation sequencing, especially in diabetic foot ulcers and chemotherapy-associated neutropenic fever.
Currently Dr. Watts is utilizing next-generation sequencing to perform whole genome analysis of pathogens in clinical infection to improve diagnosis rates and accuracy. Dr. Watts has developed methods to isolate pathogens from swabs, tissues, and whole blood that allow both 16s rRNA sequencing and whole genome sequencing. In collaboration with Dr. Bonnie Hurwitz (Department of Agricultural and Biosystems Engineering), Dr. David Armstrong (Southern Arizona Limb Salvage Alliance) and Dr. Lee Cranmer (University of Arizona Cancer Center), Dr. Watts is testing next-generation sequencing in diabetic foot ulcers and neutropenic fever patients.
Jandova J, Mason CJ, Pawar SC, Watts GS. Fn14 receptor promotes invasive potential and metastatic capacity of nonsmall lung adenocarcinoma cells through the upregulation of integrin α6. Neoplasma. 2015;62(1):4152. PubMed PMID: 25563366; NIHMSID: NIHMS693528; PubMed Central PMCID: PMC4455767.
Rankin TM, Giovinco NA, Cucher DJ, Watts G, Hurwitz B, et al. Three dimensional printing surgical instruments: are we there yet?. J Surg Res. 2014 Jun 15;189(2):1937. PubMed PMID: 24721602.
White AG, Watts GS, Lu Z, MezaMontenegro MM, Lutz EA, et al. Environmental arsenic exposure and microbiota in induced sputum. Int J Environ Res Public Health. 2014 Feb 21;11(2):2299313. PubMed PMID: 24566055; PubMed Central PMCID: PMC3945600.
Garbe JC, Vrba L, Sputova K, Fuchs L, Novak P, et al. Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle. 2014;13(21):342335. PubMed PMID: 25485586.