Arizona Health Sciences

Tally Largent-Milnes, Ph.D.

Research Assistant Professor, Pharmacology

Contact Information

Building: Life Sciences North
Phone: (520) 626-7218

Email: vhealey@email.arizona.edu

  • 2005 - BS, University of Arizona (Chemistry/Biochemistry
  • 2010 - Ph.D., University of Arziona, College of Medicine

Dr. Tally Largent-Milnes’ research focus is on uncovering pathological mechanisms and therapeutic targets for migraine headache and chronic neuropathic pain. Experiments in the Largent-Milnes laboratory have focused on dynamic regulation of the blood brain barrier in Brain/Brainstem regions associated with cortical spreading depression and migraine, synaptic physiology of the trigeminal nucleus caudalis, and drug delivery of analgesics during episodes of pain. In collaboration with Dr. Todd Vanderah, we have recently identified a novel driver of dopamine release in the reward circuitry that contributes to the likeability of common opioid therapeutics. The Largent-Milnes lab uses a complementary approach incorporating behavioral measurements, pharmacology, in vitro electrophysiology, immunohistochemistry/ tract-tracing, and in situ brain perfusion into most experimental paradigms. My lab collaborates within our department between the Blood Brain Barrier and Pain groups as well as with The Center for Innovation in Brain Science, the Departments of Surgery, Emergency Medicine, Physiology, and Pathology.

Research Interests: 
  • Blood Brain Barrier
  • Chronic Pain
  • Headache
  • Drug Delivery
  • Drug Discovery
  • Neuroscience/Neuropharmacology
  • Sex Differences
  • Synaptic physiology
  • TBI
Honors and Awards: 
2011 - NIH Individual NRSA Fellowship

 

Publications

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008