Arizona Health Sciences

Publications

Year of Publication Titlesort descending Faculty Association
2015 (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5. Rajesh Khanna, May Khanna, Ph.D.
2016 (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Rajesh Khanna, May Khanna, Ph.D., Amol Patwardhan, M.D., Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD, Yanhua Xie, Ph.D.
2016 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion. John M. Streicher, Ph.D.
2015 A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Rajesh Khanna, May Khanna, Ph.D., Tally Largent-Milnes, Ph.D., Todd Vanderah, PhD
2017 A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function. Rajesh Khanna
2013 Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Thomas P Davis, PhD, Patrick T Ronaldson, PhD, Todd Vanderah, PhD
2012 Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord. Josephine Lai , Ph.D., Tally Largent-Milnes, Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD
2012 Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Frank Porreca, PhD, Todd Vanderah, PhD
2017 Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice. John M. Streicher, Ph.D.
2014 Animal models for opioid addiction drug discovery. Tally Largent-Milnes, Ph.D., Todd Vanderah, PhD
2014 Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand. John M. Streicher, Ph.D.
2017 Blocking CRMP2 SUMOylation reverses neuropathic pain. Rajesh Khanna
2013 Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. Victor Hruby, Ph.D., Tally Largent-Milnes, Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD
2013 Cancer-induced bone pain: Mechanisms and models. Todd Vanderah, PhD
2003 Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. John M. Streicher, Ph.D.
2015 Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels. Rajesh Khanna
2014 Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt. John M. Streicher, Ph.D.
2015 Collapsin response mediator protein 3 increases the dendritic arborization of hippocampal neurons. Rajesh Khanna
2010 Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. John M. Streicher, Ph.D.
2015 CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling. Rajesh Khanna
2013 Development of functionally selective, small molecule agonists at kappa opioid receptors. John M. Streicher, Ph.D.
2014 Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides. Rajesh Khanna, May Khanna, Ph.D.
2014 Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury. Rajesh Khanna
2012 Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. John M. Streicher, Ph.D.
2014 Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Victor Hruby, Ph.D., Josephine Lai , Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD, Yanhua Xie, Ph.D.

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