Arizona Health Sciences

Regulation of gene expression and mitochondrial dynamics by SMAD.

TitleRegulation of gene expression and mitochondrial dynamics by SMAD.
Publication TypeJournal Article
Year of Publication2016
AuthorsShah N, Lee NY
JournalMol Cell Oncol
Volume3
Issue5
Paginatione1204492
Date Published2016
ISSN2372-3556
Abstract

Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

DOI10.1080/23723556.2016.1204492
Alternate JournalMol Cell Oncol
PubMed ID27857972
PubMed Central IDPMC5068171
Grant ListR01 CA178443 / CA / NCI NIH HHS / United States
Faculty Member Reference: 
Nam Lee, Ph.D.