- Development of neuroprotective and vascular protective therapies for ischemic stroke and cerebral hypoxia
- Molecular pharmacology of transporters
- Physiology of the blood-brain barrier
- Drug delivery to the brain
- Intracellular signaling mechanisms
Patrick T Ronaldson, PhD
Associate Professor, Pharmacology, Associate Professor, Neuroscience - GIDP, Associate Professor, Physiological Sciences - GIDP
Contact InformationOffice: 541
Building: Life Sciences North
Phone: (520) 626-2173
Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.
Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?
Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor.
Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke.
Highlights From the AM Assoc of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations
Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury.
Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: relevance to CNS drug delivery.