Arizona Health Sciences

Highlights From the AM Assoc of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations

TitleHighlights From the AM Assoc of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations
Publication TypeJournal Article
Year of Publication2016
AuthorsRonaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW
JournalClin Pharmacol Ther
Volume100
Issue5
Pagination419-422
Date Published2016 Nov
ISSN1532-6535
KeywordsAnimals, Blood-Brain Barrier, Humans, Membrane Transport Proteins, Models, Animal, Organic Anion Transporters, United States
Abstract

The American Association of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in absorption, distribution, metabolism, and excretion was held with the objective of discussing innovative advances in transporter pharmacology. Specific topics included (i) transporters at the blood-brain barrier (BBB); (ii) emerging transport proteins; (iii) recent advances in achieving hepatoselectivity and optimizing clearance for organic anion-transporting polypeptide (OATP) substrates; (iv) utility of animal models for transporter studies; and (v) clinical correlation of transporter polymorphisms. Here, we present state-of-the-art highlights from this workshop in these key areas of focus.

DOI10.1002/cpt.439
Alternate JournalClin. Pharmacol. Ther.
PubMed ID27500791
PubMed Central IDPMC5466066
Grant ListR01 NS084941 / NS / NINDS NIH HHS / United States
Faculty Member Reference: 
Patrick T Ronaldson, Ph.D.