Arizona Health Sciences

Use of Animal Models in Understanding Cancer-induced Bone Pain.

TitleUse of Animal Models in Understanding Cancer-induced Bone Pain.
Publication TypeJournal Article
Year of Publication2015
AuthorsSlosky LM, Largent-Milnes TM, Vanderah TW
JournalCancer Growth Metastasis
Volume8
IssueSuppl 1
Pagination47-62
Date Published2015
ISSN1179-0644
Abstract

Many common cancers have a propensity to metastasize to bone. Although malignancies often go undetected in their native tissues, bone metastases produce excruciating pain that severely compromises patient quality of life. Cancer-induced bone pain (CIBP) is poorly managed with existing medications, and its multifaceted etiology remains to be fully elucidated. Novel analgesic targets arise as more is learned about this complex and distinct pain state. Over the past two decades, multiple animal models have been developed to study CIBP's unique pathology and identify therapeutic targets. Here, we review animal models of CIBP and the mechanistic insights gained as these models evolve. Findings from immunocompromised and immunocompetent host systems are discussed separately to highlight the effect of model choice on outcome. Gaining an understanding of the unique neuromolecular profile of cancer pain through the use of appropriate animal models will aid in the development of more effective therapeutics for CIBP.

DOI10.4137/CGM.S21215
Alternate JournalCancer Growth Metastasis
PubMed ID26339191
PubMed Central IDPMC4552039
Faculty Member Reference: 
Tally Largent-Milnes, Ph.D.
Todd Vanderah, PhD