Arizona Health Sciences

All Events (past)

Wed, 03/23/2016 - 11:00am to 12:00pm Graduate Student Seminar

"TGF-β/ALK-1 Signaling: Regulation of Oatp1a4

Expression at the Blood-Brain Barrier"

By

Wazir Abdullahi, Ph.D. Student

Department of Pharmacology

Dr. Patrick Ronaldson’s Laboratory

and

"Polar Shot (ALM) Cardioplegia in the Clinical Arena:

The Saga Continues"

By

Ashley Risso, MS Perfusion Sciences Student

Department of Pharmacology

Dr. Ray Wong

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 03/16/2016 - 11:00am to 12:00pm Department of Pharmacology Graduate Student Seminar

CANCELLED

 

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 03/09/2016 - 11:00am to 12:00pm Department of Pharmacology Graduate Student Seminar

"New approaches to optimizing vascular remodeling and bloodbrain barrier integrity of cerebral blood vessels"

by

Richard Milner, M.D., Ph.D.
Associate Professor
Department of Molecular and Experimental Medicine
The Scripps Research Institute

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 03/02/2016 - 11:00am to 12:00pm Graduate Student Seminar

"The Evolution of Cannabis"

by

Steven P. Bennett, Ph.D.
Scientific Director Evolab

Clinical cannabis research in the US is very limited under federal law.  Since the government has designated cannabis to Schedule I, denoting lack of therapeutic benefit, conducting classical clinical trials is virtually prohibited.  In some cases, observational studies can be conducted using patient feedback if the proper medical oversight is applied (Internal Review Boards, Investigational New Drug applications) and the funds are provided by the state or a private source.  These studies, however, are generally limited in that the feedback is rather subjective and not the result of statistically derived, publishable data from randomized, placebo-controlled studies.  Moreover, cannabis is unlike any drug that has been approved by the FDA, since it is not a single molecule with a single mechanism of action, but rather an entourage of numerous cannabinoids and terpenes on 2 types of receptors (CB1 and CB2) which vary in location, receptor density, and elicit a variety of physiological responses. This information, when combined with our knowledge of variability in each individual’s endocannabinoid system, makes cannabis-based research particularly challenging.  Notwithstanding, numerous benefits have been reported and it has become a medical imperative to thoroughly investigate cannabis-derived therapies.

                In this talk, I wish to outline the current medical applications of cannabis, drug mechanism(s), delivery mechanisms, observational studies, clinical trials, and also discuss product development at Evolab.  My hope is to engage both the bench scientists and the entrepreneurs in the group, alike.  Ultimately, this is a topic that means something different to everyone and I want to deliver a presentation that accounts for this diversity.

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 02/24/2016 - 12:00pm to 1:15pm IDEA to ASSET Seminar

"Protecting and Licensing Intellectual Property"

by

Rajesh Khanna, Ph.D.
Department of Pharmacology
UA College of Medicine

David Casimir, J.D., Ph.D.
Casimir Jones, S.C.

Robert Goetz, J.D., M.S.
Casimir Jones, S.C.

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 02/17/2016 - 11:00am to 12:00pm Graduate Student Seminar

"Combinational treatment approach for Traumatic Spinal Cord Injury"

by

Melissa Jane Walker, Ph.D.
Postdoctoral Candidate
Medical Neuroscience Program and Spinal Cord
and Brain Injury Research Group
Indiana University School of Medicine

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 02/10/2016 - 11:00am to 12:00pm Graduate Student Seminar

"Protease Activated Receptor 2 Modulators"

Endogenous proteases, in addition to their first accepted role as degradative enzymes, contribute to many pathological processes through the direct activation of protease activated receptors. This four member family of G-protein coupled receptors (GPCRs) includes the thrombin receptor (protease activated receptor-1; PAR1) and three other members (PAR2, PAR3, PAR4). PAR2 is known to play an important role in pathologies that are associated with a release of proteases; these include asthma, chronic pain, cancer, vascular diseases, and inflammatory conditions in general. Much of our knowledge of PAR2 function is due to the availability of PAR2 knockout models and peptide/peptidomimetic agonists. However, possible efficacy of PAR2 antagonists in preclinical models has been limited due to lack of available tools or clinical candidate compounds. The primary objectives of our research are to develop PAR2 modulators (biased antagonists and agonists) and use our established discovery pipeline and pharmacological tools to design new PAR2 modulators with improved drug-like properties to probe PAR2 function in the context of animal models (pain and asthma). We have developed a panel of unique PAR2 modulator: (i) the most potent, specific and efficacious PAR2 agonists to date; (ii) a potent and specific peptidomimetic antagonist C291 (blocking multiple signaling pathways(Gq-dependent iCa2+ release and MAPK); and (iii) biased antagonist of  iCa2+ release (without stimulation or inhibition of MAPK).

In current study, we work on transition of these compounds into “drug lead” compounds and to fully evaluate PAR2 ligand potency/efficacy in context of different signaling pathways.

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 02/03/2016 - 11:00am to 12:00pm Department of Pharmacology Graduate Student Seminar

CANCELLED

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 01/27/2016 - 11:00am to 12:00pm Department of Pharmacology Graudate Student Seminar

"Isoform Specific Protein Targeting"

by

Eli Chapman, Ph.D.,
Assistant Professor
Department of Pharmacology and Toxicology
College of Pharmacy

 

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 01/20/2016 - 11:00am to 12:00pm Department of Pharmacology Graduate Student Seminar

"It's all in your head:  Exploring our emotion center in opioid-sensitive descening pain modulatory circuitry"

by

Lusine Gomtsian, Ph.D. Student,
Department of Pharmacology
Dr. Frank Porreca's Laboratory

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 01/20/2016 - 11:00am to 12:00pm Department of Pharmacology Graduate Student Seminar

"Its all in your head: Exploring our emotion center in opioid-sensitive descending pain modulatory circuitry"

by

Lusine Gomtsian, Ph.D. Student
Department of Pharmacology
Dr. Frank Porreca's Laboratory

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 01/13/2016 - 11:00am to 12:00pm Graduate Student Seminar

Graduate Student Seminar - TBD

1501 N. Campbell Ave.
Tucson, AZ 85724
Mon, 01/11/2016 - 11:00am to 12:00pm Test Spring Program Seminar

This is a test Event, so that there can be an event showing up on the Program Seminars page. Events taking place between Jan 1, 2016 and July 1, 2016, that are tagged "Student Research Seminar (PHCL 596C)" as their Event Type will show up on the Program Seminars page. To get rid of this event, click on the event title, then Edit, then Delete.

1501 N. Campbell Ave.
Tucson, AZ 85724
Wed, 05/06/2015 - 11:00am to 12:00pm Research Seminar: Karissa Cottier, Ph.D. Student and Lusine Gomtsian, Ph.D. Student

PHCL 596C - Critical Literature Review & Research Seminar

Karissa Cottier, Ph.D. Student and Lusine Gomtsian, Ph.D. Student, Department of Pharmacology, University of Arizona

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 04/29/2015 - 11:00am to 12:00pm Research Seminar: Jennifer Arriola and Jessica Ortiz

PHCL 596C - Critical Literature Review & Research Seminar

Jennifer Arriola, M.S. Student and Jessica Ortiz, M.S. Student, Department of Pharmacology, University of Arizona

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 04/22/2015 - 11:00am to 12:00pm Research Seminar: Shaness Grenald

PHCL 596C - Critical Literature Review & Research Seminar

Shaness Grenald, Ph.D. Student, Department of Pharmacology, University of Arizona.

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 04/15/2015 - 11:00am to 12:00pm Research Seminar: Alexander Sandweiss and Kayla Gardner

PHCL 596C - Critical Literature Review & Research Seminar

Alexander Sandweiss, Ph.D. Student and Kayla Gardner, MS Student, Department of Pharmacology, University of Arizona

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 04/08/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 04/01/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 03/25/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 03/18/2015 - 11:00am to 12:00pm Research Seminar: Spring Break – No Seminar

PHCL 596C - Critical Literature Review & Research Seminar

Spring Break – No Seminar

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 03/11/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 03/04/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

 

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 02/25/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724
Wed, 02/18/2015 - 11:00am to 12:00pm Research Seminar: TBD

PHCL 596C - Critical Literature Review & Research Seminar

TBD

1501 N. Campbell Ave.
AHSC 8403
Tucson, AZ 85724

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