Associate Department Head, PharmacologyProfessor, AnesthesiologyProfessor, Cancer Biology - GIDPProfessor, Neuroscience - GIDPProfessor, Pharmacology
Neurobiology of pain.
(S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord.
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.