Biblio

Found 13 results
Filters: Author is Streicher, John M and Keyword is Analgesics, Opioid  [Clear All Filters]
2024
Duron DI, Tanguturi P, Campbell CS, Chou K, Bejarano P, Gabriel KA, Bowden JL, Mishra S, Brackett C, Barlow D et al..  2024.  Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment.. Sci Rep. 14(1):14715.
2023
Gabriel KA, Streicher JM.  2023.  HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop.. Sci Signal. 16(780):eade2438.
Varga BR, Streicher JM, Majumdar S.  2023.  Strategies towards safer opioid analgesics-A review of old and upcoming targets.. Br J Pharmacol. 180(7):975-993.
2022
Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR et al..  2022.  Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling.. Pain. 163(1):146-158.
2021
Tanguturi P, Pathak V, Zhang S, Moukha-Chafiq O, Augelli-Szafran CE, Streicher JM.  2021.  Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists.. Molecules. 26(21)
2020
Duron DI, Hanak F, Streicher JM.  2020.  Daily intermittent fasting in mice enhances morphine-induced antinociception while mitigating reward, tolerance, and constipation.. Pain. 161(10):2353-2363.
Stine C, Coleman DL, Flohrschutz AT, Thompson AL, Mishra S, Blagg BS, Largent-Milnes TM, Lei W, Streicher JM.  2020.  Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.. Pain. 161(8):1798-1807.
Lei W, Vekariya RH, Ananthan S, Streicher JM.  2020.  A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.. J Pain. 21(1-2):146-160.
2019
Olson KM, Duron DI, Womer D, Fell R, Streicher JM.  2019.  Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids.. PLoS One. 14(6):e0217371.
2018
Streicher JM, Bilsky EJ.  2018.  Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications.. J Pharm Pract. 31(6):658-669.
2017
Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, Edwards K, Bilsky EJ, Streicher JM.  2017.  Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.. J Biol Chem. 292(25):10414-10428.
2016
Zhang Y, Williams DA, Zaidi SA, Yuan Y, Braithwaite A, Bilsky EJ, Dewey WL, Akbarali HI, Streicher JM, Selley DE.  2016.  17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.. ACS Chem Neurosci. 7(3):297-304.
2011
Tarselli MA, Raehal KM, Brasher AK, Streicher JM, Groer CE, Cameron MD, Bohn LM, Micalizio GC.  2011.  Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain.. Nat Chem. 3(6):449-53.