Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

TitleBuchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
Publication TypeJournal Article
Year of Publication2019
AuthorsRenault YJG, Lynch R, Marelli E, Sharma SV, Pubill-Ulldemolins C, Sharp JA, Cartmell C, Cárdenas P, Goss RJM
JournalChemical Communications
Abstract

Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin.

Faculty Member Reference: 
Christopher Cartmell