| Title | Discovery of Levesquamide B through Global Natural Product Social Molecular Networking. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | LeClair MM, Maw ZA, Grunwald AL, Kelly JR, Haltli BA, Kerr RG, Cartmell C |
| Journal | Molecules |
| Volume | 27 |
| Issue | 22 |
| Date Published | 2022 Nov 12 |
| ISSN | 1420-3049 |
| Keywords | Biological Products, Streptomyces |
| Abstract | Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous. |
| DOI | 10.3390/molecules27227794 |
| Alternate Journal | Molecules |
| PubMed ID | 36431895 |
| PubMed Central ID | PMC9695545 |
Faculty Member Reference:
Christopher Cartmell