Biblio
Found 29 results
Filters: Author is Streicher, John M and Keyword is Animals [Clear All Filters]
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2025. Select terpenes from Cannabis sativa are antinociceptive in mouse models of post-operative pain and fibromyalgia via adenosine A receptors.. Pharmacol Rep. 77(1):172-181.
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2024. Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment.. Sci Rep. 14(1):14715.
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2024. Select Minor Cannabinoids from Are Cannabimimetic and Antinociceptive in a Mouse Model of Chronic Neuropathic Pain.. J Pharmacol Exp Ther. 391(2):214-221.
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2023. HSP90 inhibition in the mouse spinal cord enhances opioid signaling by suppressing an AMPK-mediated negative feedback loop.. Sci Signal. 16(780):eade2438.
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2021. Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity.. Sci Rep. 11(1):8232.
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2020. Daily intermittent fasting in mice enhances morphine-induced antinociception while mitigating reward, tolerance, and constipation.. Pain. 161(10):2353-2363.
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2020. The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor.. Pharmacol Rep. 72(2):465-471.
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2020. Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.. Pain. 161(8):1798-1807.
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2020. Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.. Sci Signal. 13(630)
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2020. A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.. J Pain. 21(1-2):146-160.
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2019. Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids.. PLoS One. 14(6):e0217371.
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2018. A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain.. J Pain. 19(6):612-625.
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2018. Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications.. J Pharm Pract. 31(6):658-669.
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2018. Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice.. J Med Chem. 61(14):6075-6086.
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2018. TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.. Nat Commun. 9(1):1696.
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2017. Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.. J Biol Chem. 292(25):10414-10428.
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2017. Synergistic interaction of the cannabinoid and death receptor systems - a potential target for future cancer therapies? FEBS Lett. 591(20):3235-3251.
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2016. 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.. ACS Chem Neurosci. 7(3):297-304.
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2015. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.. Bioorg Med Chem. 23(14):3948-56.
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2013. Development of functionally selective, small molecule agonists at kappa opioid receptors.. J Biol Chem. 288(51):36703-16.
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2013. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.. J Biol Chem. 288(31):22387-98.
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2011. Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain.. Nat Chem. 3(6):449-53.