|Title||Glial neuroimmune signaling in opioid reward.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Zhang H, Largent-Milnes TM, Vanderah TW|
|Journal||Brain Res Bull|
|Date Published||2020 02|
|Keywords||Animals, Astrocytes, Brain, Humans, Microglia, Neuroglia, Neuroimmunomodulation, Opioid-Related Disorders, Reward, Signal Transduction|
The opioid epidemic is a growing public concern affecting millions of people worldwide. Opioid-induced reward is the initial and key process leading to opioid abuse and addiction. Therefore, a better understanding of opioid reward may be helpful in developing a treatment for opioid addiction. Emerging evidence suggests that glial cells, particularly microglia and astrocytes, play an essential role in modulating opioid reward. Indeed, glial cells and their associated immune signaling actively regulate neural activity and plasticity, and directly modulate opioid-induced rewarding behaviors. In this review, we describe the neuroimmune mechanisms of how glial cells affect synaptic transmission and plasticity as well as how opioids can activate glial cells affecting the glial-neuronal interaction. Last, we summarize current attempts of applying glial modulators in treating opioid reward.
|Alternate Journal||Brain Res Bull|
|PubMed Central ID||PMC6946383|
|Grant List||R01 CA142115 / CA / NCI NIH HHS / United States|
Glial neuroimmune signaling in opioid reward.
Faculty Member Reference:
Tally Largent-Milnes, PhD
Todd Vanderah, PhD