Glial neuroimmune signaling in opioid reward.

TitleGlial neuroimmune signaling in opioid reward.
Publication TypeJournal Article
Year of Publication2020
AuthorsZhang H, Largent-Milnes TM, Vanderah TW
JournalBrain Res Bull
Date Published2020 02
KeywordsAnimals, Astrocytes, Brain, Humans, Microglia, Neuroglia, Neuroimmunomodulation, Opioid-Related Disorders, Reward, Signal Transduction

The opioid epidemic is a growing public concern affecting millions of people worldwide. Opioid-induced reward is the initial and key process leading to opioid abuse and addiction. Therefore, a better understanding of opioid reward may be helpful in developing a treatment for opioid addiction. Emerging evidence suggests that glial cells, particularly microglia and astrocytes, play an essential role in modulating opioid reward. Indeed, glial cells and their associated immune signaling actively regulate neural activity and plasticity, and directly modulate opioid-induced rewarding behaviors. In this review, we describe the neuroimmune mechanisms of how glial cells affect synaptic transmission and plasticity as well as how opioids can activate glial cells affecting the glial-neuronal interaction. Last, we summarize current attempts of applying glial modulators in treating opioid reward.

Alternate JournalBrain Res Bull
PubMed ID31790721
PubMed Central IDPMC6946383
Grant ListR01 CA142115 / CA / NCI NIH HHS / United States
Faculty Member Reference: 
Tally Largent-Milnes, PhD
Todd Vanderah, PhD