Patrick T Ronaldson, PhD, FAAPS

Professor, Pharmacology, Professor, Neuroscience - GIDP, Professor, Physiological Sciences - GIDP

Contact Information

Office: 560
Building: Life Sciences North
Phone: (520) 626-2173

Email: pronald@arizona.edu
Fellowship: 
2008-2010 - University of Arizona Pharmacology; 2007-2008 University of Toronto, Pharmaceutical Sciences
Research Area: 
Molecular and Biochemical Pharmacology
Neuroscience and Pain
Toxicology
Research Interests: 
  • Development of neuroprotective and vascular protective therapies for ischemic stroke and cerebral hypoxia
  • Molecular pharmacology of transporters
  • Physiology of the blood-brain barrier
  • Drug delivery to the brain
  • Intracellular signaling mechanisms 
  • Neurotoxicology

 

Publications

2022

Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats.

Transport Mechanisms at the Blood-Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs.

Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins).

Blood-Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke.

High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats.

2021

Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor- Signaling in Human Endothelial Cells.

2020

Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke.

Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity.

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders.

2018

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection.

2017

Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.

Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor.

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.

Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?

Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke.

2016

Highlights From the AM Assoc of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations

2015

Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury.

2014

Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: relevance to CNS drug delivery.

Drug delivery to the ischemic brain.

2012

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain.