Title | Highlights From the AM Assoc of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW |
Journal | Clin Pharmacol Ther |
Volume | 100 |
Issue | 5 |
Pagination | 419-422 |
Date Published | 2016 Nov |
ISSN | 1532-6535 |
Keywords | Animals, Blood-Brain Barrier, Humans, Membrane Transport Proteins, Models, Animal, Organic Anion Transporters, United States |
Abstract | The American Association of Pharmaceutical Scientists/International Transporter Consortium Joint Workshop on Drug Transporters in absorption, distribution, metabolism, and excretion was held with the objective of discussing innovative advances in transporter pharmacology. Specific topics included (i) transporters at the blood-brain barrier (BBB); (ii) emerging transport proteins; (iii) recent advances in achieving hepatoselectivity and optimizing clearance for organic anion-transporting polypeptide (OATP) substrates; (iv) utility of animal models for transporter studies; and (v) clinical correlation of transporter polymorphisms. Here, we present state-of-the-art highlights from this workshop in these key areas of focus. |
DOI | 10.1002/cpt.439 |
Alternate Journal | Clin. Pharmacol. Ther. |
PubMed ID | 27500791 |
PubMed Central ID | PMC5466066 |
Grant List | R01 NS084941 / NS / NINDS NIH HHS / United States |
Faculty Member Reference:
Patrick T Ronaldson, PhD, FAAPS