Perimenopause as a neurological transition state.

TitlePerimenopause as a neurological transition state.
Publication TypeJournal Article
Year of Publication2015
AuthorsBrinton RD, Yao J, Yin F, Mack WJ, Cadenas E
JournalNat Rev Endocrinol
Date Published2015 Jul
KeywordsAffect, Anxiety, Arousal, Attention, Brain, Cognition, Eating, Estrogens, Executive Function, Female, Humans, Learning, Memory, Perimenopause, Receptors, Estrogen

Perimenopause is a midlife transition state experienced by women that occurs in the context of a fully functioning neurological system and results in reproductive senescence. Although primarily viewed as a reproductive transition, the symptoms of perimenopause are largely neurological in nature. Neurological symptoms that emerge during perimenopause are indicative of disruption in multiple estrogen-regulated systems (including thermoregulation, sleep, circadian rhythms and sensory processing) and affect multiple domains of cognitive function. Estrogen is a master regulator that functions through a network of estrogen receptors to ensure that the brain effectively responds at rapid, intermediate and long timescales to regulate energy metabolism in the brain via coordinated signalling and transcriptional pathways. The estrogen receptor network becomes uncoupled from the bioenergetic system during the perimenopausal transition and, as a corollary, a hypometabolic state associated with neurological dysfunction can develop. For some women, this hypometabolic state might increase the risk of developing neurodegenerative diseases later in life. The perimenopausal transition might also represent a window of opportunity to prevent age-related neurological diseases. This Review considers the importance of neurological symptoms in perimenopause in the context of their relationship to the network of estrogen receptors that control metabolism in the brain.

Alternate JournalNat Rev Endocrinol
PubMed ID26007613
Grant ListP01AG026572 / AG / NIA NIH HHS / United States
R01-AG032236 / AG / NIA NIH HHS / United States
Faculty Member Reference: 
Roberta Diaz Brinton, Ph.D
Fei Yin, Ph.D.