Edita Navratilova

Associate Professor, Pharmacology

Member of the Graduate Faculty

517

edita@arizona.edu

Research Interests

Neuropharmacology of pain; brain circuits for pain, relief of pain and reward; opioid neurotransmission; mechanisms of acute and chronic pain.

Publications

Ito, Hisakatsu, et al. “Chronic Pain Recruits Hypothalamic Dynorphin Kappa Opioid Receptor Signalling to Promote Wakefulness and Vigilance.”. Brain, vol. 146, no. 3, Jan. 2023, pp. 1186-99, https://doi.org/10.1093/brain/awac153.

Navratilova, Edita, et al. “Preclinical Assessment of OnabotulinumtoxinA for the Treatment of Mild Traumatic Brain Injury-Related Acute and Persistent Post-Traumatic Headache.”. Cephalalgia, vol. 42, no. 11-12, Oct. 2022, pp. 1194-06, https://doi.org/10.1177/03331024221099841.

Ikegami, Daigo, et al. “A Prolactin-Dependent Sexually Dimorphic Mechanism of Migraine Chronification.”. Cephalalgia, vol. 42, no. 3, Mar. 2022, pp. 197-08, https://doi.org/10.1177/03331024211039813.

Watanabe, Moe, et al. “Dysregulation of Serum Prolactin Links the Hypothalamus With Female Nociceptors to Promote Migraine.”. Brain, vol. 145, no. 8, Jan. 2022, pp. 2894-09, https://doi.org/10.1093/brain/awac104.

Kopruszinski, Caroline M, et al. “Exploring the Neurobiology of the Premonitory Phase of Migraine Preclinically - a Role for Hypothalamic Kappa Opioid Receptors?”. J Headache Pain, vol. 23, no. 1, Jan. 2022, p. 126, https://doi.org/10.1186/s10194-022-01497-7.

Yakhnitsa, Vadim, et al. “Kappa Opioid Receptor Blockade in the Amygdala Mitigates Pain Like-Behaviors by Inhibiting Corticotropin Releasing Factor Neurons in a Rat Model of Functional Pain.”. Front Pharmacol, vol. 13, Jan. 2022, p. 903978, https://doi.org/10.3389/fphar.2022.903978.

Lançon, Kevin, et al. “Decreased Dopaminergic Inhibition of Pyramidal Neurons in Anterior Cingulate Cortex Maintains Chronic Neuropathic Pain.”. Cell Rep, vol. 37, no. 9, Jan. 2021, p. 109933, https://doi.org/10.1016/j.celrep.2021.109933.

Xie, Jennifer Y, et al. “Kappa Opioid Receptor Antagonists: A Possible New Class of Therapeutics for Migraine Prevention.”. Cephalalgia, vol. 37, no. 8, July 2017, pp. 780-94, https://doi.org/10.1177/0333102417702120.

Nair, Padma, et al. “Truncation of the Peptide Sequence in Bifunctional Ligands With Mu and Delta Opioid Receptor Agonist and Neurokinin 1 Receptor Antagonist Activities.”. Bioorg Med Chem Lett, vol. 23, no. 17, Jan. 2013, pp. 4975-8, https://doi.org/10.1016/j.bmcl.2013.06.065.

Nair, Padma, et al. “Novel Bifunctional Peptides As Opioid Agonists and NK-1 Antagonists”. Adv Exp Med Biol, vol. 611, Jan. 2009, pp. 537-8.