Patrick T Ronaldson, PhD, FAAPS

Chair, Neuroscience - GIDP

Member of the Graduate Faculty

Professor, Neuroscience - GIDP

Professor, Pharmacology

Professor, Physiological Sciences - GIDP

560

pronald@arizona.edu

Degrees

2008-2010 - University of Arizona Pharmacology; 2007-2008 University of Toronto, Pharmaceutical Sciences

Research Interests

Development of neuroprotective and vascular protective therapies for ischemic stroke and cerebral hypoxia
Molecular pharmacology of transporters
Physiology of the blood-brain barrier
Drug delivery to the brain
Intracellular signaling mechanisms
Neurotoxicology

Publications

Stanton, Joshua A, et al. “Targeting Organic Cation Transporters at the Blood-Brain Barrier to Treat Ischemic Stroke in Rats.”. Exp Neurol, vol. 357, Nov. 2022, p. 114181, https://doi.org/10.1016/j.expneurol.2022.114181.

Betterton, Robert D, et al. “Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.E., Statins).”. Drug Metab Dispos, vol. 50, no. 7, July 2022, pp. 942-56, https://doi.org/10.1124/dmd.121.000781.

Nilles, Kelsy L, et al. “Blood-Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke.”. Int J Mol Sci, vol. 23, no. 3, Jan. 2022, https://doi.org/10.3390/ijms23031898.

Yang, Junzhi, et al. “High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats.”. Pharmaceutics, vol. 14, no. 5, Jan. 2022, https://doi.org/10.3390/pharmaceutics14050949.

Ronaldson, Patrick T, and Davis, Thomas P. “Transport Mechanisms at the Blood-Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs.”. Pharmaceutics, vol. 14, no. 7, Jan. 2022, https://doi.org/10.3390/pharmaceutics14071501.

Ronaldson, Patrick T, et al. “Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor- Signaling in Human Endothelial Cells.”. J Pharmacol Exp Ther, vol. 376, no. 2, Feb. 2021, pp. 148-60, https://doi.org/10.1124/jpet.120.000267.

Ronaldson, Patrick T, and Davis, Thomas P. “Regulation of Blood-Brain Barrier Integrity by Microglia in Health and Disease: A Therapeutic Opportunity.”. J Cereb Blood Flow Metab, vol. 40, no. 1_suppl, Dec. 2020, pp. S6-S24, https://doi.org/10.1177/0271678X20951995.

Lochhead, Jeffrey J, et al. “Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders.”. Front Physiol, vol. 11, Jan. 2020, p. 914, https://doi.org/10.3389/fphys.2020.00914.

Williams, Erica I, et al. “Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke.”. Pharmaceutics, vol. 12, no. 2, Jan. 2020, https://doi.org/10.3390/pharmaceutics12020154.

Abdullahi, Wazir, et al. “Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection.”. Am J Physiol Cell Physiol, vol. 315, no. 3, Jan. 2018, pp. C343-C356, https://doi.org/10.1152/ajpcell.00095.2018.

Abdullahi, Wazir, et al. “Bone Morphogenetic Protein-9 Increases the Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier via the Activin Receptor-Like Kinase-1 Receptor.”. J Cereb Blood Flow Metab, vol. 37, no. 7, July 2017, pp. 2340-5, https://doi.org/10.1177/0271678X17702916.

Abdullahi, Wazir, et al. “Functional Expression of P-Glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?”. AAPS J, vol. 19, no. 4, July 2017, pp. 931-9, https://doi.org/10.1208/s12248-017-0081-9.

Lochhead, Jeffrey J, et al. “Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System.”. AAPS J, vol. 19, no. 4, July 2017, pp. 910-2, https://doi.org/10.1208/s12248-017-0076-6.

Ibbotson, Kathryn, et al. “Nrf2 Signaling Increases Expression of ATP-Binding Cassette Subfamily C MRNA Transcripts at the Blood-Brain Barrier Following Hypoxia-Reoxygenation Stress.”. Fluids Barriers CNS, vol. 14, no. 1, Jan. 2017, p. 6, https://doi.org/10.1186/s12987-017-0055-4.

Brzica, Hrvoje, et al. “Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke.”. J Cent Nerv Syst Dis, vol. 9, Jan. 2017, p. 1179573517693802, https://doi.org/10.1177/1179573517693802.

Ronaldson, Patrick T, and Davis, Thomas P. “Targeting Transporters: Promoting Blood-Brain Barrier Repair in Response to Oxidative Stress Injury.”. Brain Res, vol. 1623, Jan. 2015, pp. 39-52, https://doi.org/10.1016/j.brainres.2015.03.018.

Thompson, Brandon J, et al. “Hypoxia/Reoxygenation/Stress/Signals/an/Increase/in/Organic/Anion/Transporting/Polypeptide/1a4/(Oatp1a4)/at/the/Blood-Brain/Barrier:/Relevance/to/CNS/Drug/Delivery.”. J Cereb Blood Flow Metab, vol. 34, no. 4, Apr. 2014, pp. 699-07, https://doi.org/10.1038/jcbfm.2014.4.

Thompson, Brandon J, and Ronaldson, Patrick T. “Drug Delivery to the Ischemic Brain.”. Adv Pharmacol, vol. 71, Jan. 2014, pp. 165-02, https://doi.org/10.1016/bs.apha.2014.06.013.

Lochhead, Jeffrey J, et al. “Tempol Modulates Changes in Xenobiotic Permeability and Occludin Oligomeric Assemblies at the Blood-Brain Barrier During Inflammatory Pain.”. Am J Physiol Heart Circ Physiol, vol. 302, no. 3, Jan. 2012, pp. H582-93, https://doi.org/10.1152/ajpheart.00889.2011.