Tally Largent-Milnes, PhD

Associate Professor, Pharmacology

Assistant Professor, BIO5 Institute

Member of the Graduate Faculty

621

tlargent@arizona.edu

Research Interests

Blood Brain Barrier
Chronic Pain
Headache
Drug Delivery
Drug Discovery
Neuroscience/Neuropharmacology
Sex Differences
Synaptic physiology
TBI

Publications

Martin, Laurent F, et al. “Green Light Exposure Elicits Anti-Inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-Surgical Pain.”. J Pain, vol. 24, no. 3, Mar. 2023, pp. 509-2, https://doi.org/10.1016/j.jpain.2022.10.011.

Bruhns, Ryan P, et al. “Angiotensin-(1-7) Improves Cognitive Function and Reduces Inflammation in Mice Following Mild Traumatic Brain Injury.”. Front Behav Neurosci, vol. 16, Jan. 2022, p. 903980, https://doi.org/10.3389/fnbeh.2022.903980.

Blackwell, Jade A, et al. “Cerebral Arteriolar and Neurovascular Dysfunction After Chemically Induced Menopause in Mice.”. Am J Physiol Heart Circ Physiol, vol. 323, no. 5, Jan. 2022, pp. H845-H860, https://doi.org/10.1152/ajpheart.00276.2022.

Wahl, Jared R, et al. “Extracellular Alterations in PH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.”. Pharmaceutics, vol. 14, no. 7, Jan. 2022, https://doi.org/10.3390/pharmaceutics14071469.

Palomino, Seph M, et al. “Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity After Cortical Spreading Depression.”. Pharmaceutics, vol. 14, no. 8, Jan. 2022, https://doi.org/10.3390/pharmaceutics14081665.

Bartolo, Nicole D, et al. “Radiocaine: An Imaging Marker of Neuropathic Injury.”. ACS Chem Neurosci, vol. 13, no. 24, Jan. 2022, pp. 3661-7, https://doi.org/10.1021/acschemneuro.2c00717.

Vizcarra, Velia S, et al. “Targeting 5-HT Receptors and Kv7 Channels in PFC to Attenuate Chronic Neuropathic Pain in Rats Using a Spared Nerve Injury Model.”. Neurosci Lett, vol. 789, Jan. 2022, p. 136864, https://doi.org/10.1016/j.neulet.2022.136864.

Levine, Aidan, et al. “An Underrepresented Majority: A Systematic Review Utilizing Allodynic Criteria to Examine the Present Scarcity of Discrete Animal Models for Episodic Migraine.”. Cephalalgia, vol. 41, no. 3, Jan. 2021, pp. 404-16, https://doi.org/10.1177/0333102420966984.

Blawn, Kiera T, et al. “Sex Hormones Regulate NHE1 Functional Expression and Brain Endothelial Proteome to Control Paracellular Integrity of the Blood Endothelial Barrier.”. Brain Res, vol. 1763, Jan. 2021, p. 147448, https://doi.org/10.1016/j.brainres.2021.147448.

Zhang, Hong, et al. “The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area.”. Front Pharmacol, vol. 12, Jan. 2021, p. 632757, https://doi.org/10.3389/fphar.2021.632757.

Stine, Carrie, et al. “Heat Shock Protein 90 Inhibitors Block the Antinociceptive Effects of Opioids in Mouse Chemotherapy-Induced Neuropathy and Cancer Bone Pain Models.”. Pain, vol. 161, no. 8, Aug. 2020, pp. 1798-07, https://doi.org/10.1097/j.pain.0000000000001886.

Doyle, Timothy M, et al. “Activation of Sphingosine-1-Phosphate Receptor Subtype 1 in the Central Nervous System Contributes to Morphine-Induced Hyperalgesia and Antinociceptive Tolerance in Rodents.”. Pain, vol. 161, no. 9, Jan. 2020, pp. 2107-18, https://doi.org/10.1097/j.pain.0000000000001888.

Wiese, Beth M, et al. “Cannabinoid-2 Agonism With AM2301 Mitigates Morphine-Induced Respiratory Depression.”. Cannabis Cannabinoid Res, Jan. 2020, https://doi.org/10.1089/can.2020.0076.

Levine, Aidan, et al. “DAGLα Inhibition As a Non-Invasive and Translational Model of Episodic Headache.”. Front Pharmacol, vol. 11, Jan. 2020, p. 615028, https://doi.org/10.3389/fphar.2020.615028.

Largent-Milnes, Tally M, et al. “Editorial: Novel Molecular Targets for the Treatment of Pain”. Front Mol Neurosci, vol. 13, Jan. 2020, p. 625714, https://doi.org/10.3389/fnmol.2020.625714.

Liktor-Busa, Erika, et al. “Functional NHE1 Expression Is Critical to Blood Brain Barrier Integrity and Sumatriptan Blood to Brain Uptake.”. PLoS One, vol. 15, no. 5, Jan. 2020, p. e0227463, https://doi.org/10.1371/journal.pone.0227463.

Zhang, Hong, et al. “Glial Neuroimmune Signaling in Opioid Reward.”. Brain Res Bull, vol. 155, Jan. 2020, pp. 102-11, https://doi.org/10.1016/j.brainresbull.2019.11.012.

Hay, Meredith, et al. “A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.”. J Pharmacol Exp Ther, vol. 369, no. 1, Jan. 2019, pp. 9-25, https://doi.org/10.1124/jpet.118.254854.

Thompson, Austen L, et al. “Animal Models for the Study of Bone-Derived Pain.”. Methods Mol Biol, vol. 1914, Jan. 2019, pp. 391-07, https://doi.org/10.1007/978-1-4939-8997-3_23.

Moutal, Aubin, et al. “Cdk5-Mediated CRMP2 Phosphorylation Is Necessary and Sufficient for Peripheral Neuropathic Pain.”. Neurobiol Pain, vol. 5, Jan. 2019, https://doi.org/10.1016/j.ynpai.2018.07.003.

Chen, Zhoumou, et al. “Sphingosine-1-Phosphate Receptor 1 Activation in Astrocytes Contributes to Neuropathic Pain.”. Proc Natl Acad Sci U S A, vol. 116, no. 21, Jan. 2019, pp. 10557-62, https://doi.org/10.1073/pnas.1820466116.

Zhang, Hong, et al. “Peripherally Restricted Cannabinoid 1 Receptor Agonist As a Novel Analgesic in Cancer-Induced Bone Pain.”. Pain, vol. 159, no. 9, Sept. 2018, pp. 1814-23, https://doi.org/10.1097/j.pain.0000000000001278.

Edwards, Katie A, et al. “A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain.”. J Pain, vol. 19, no. 6, Jan. 2018, pp. 612-25, https://doi.org/10.1016/j.jpain.2018.01.002.

Pandit, Viraj, et al. “Continuous Remote Ischemic Conditioning Attenuates Cognitive and Motor Deficits from Moderate Traumatic Brain Injury.”. J Trauma Acute Care Surg, vol. 85, no. 1, Jan. 2018, pp. 48-53, https://doi.org/10.1097/TA.0000000000001835.

Cottier, Karissa E, et al. “Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.”. ENeuro, vol. 5, no. 4, Jan. 2018, https://doi.org/10.1523/ENEURO.0116-18.2018.