Todd Vanderah, PhD

Co-Director, MD/PhD Dual Degree Program

Department Head, Pharmacology

Director, Comprehensive Pain and Addiction Center

Member of the Graduate Faculty

Professor, Anesthesiology

Professor, BIO5 Institute

Neurology

Professor, Neuroscience - GIDP

Professor, Pharmacology

Professor, Physiological Sciences - GIDP

Regents Professor

647

(520) 626-7801

vanderah@arizona.edu

Leadership roles: Pharmacology Executive Committee Member, Dean's Council on Faculty Affairs Director, Medical Pharmacology Graduate Program

Research Interests

Mechanisms and pharmacology of acute and chronic models of pain; endogenous opioid systems; sensory neural systems; opioid tolerance; antinociceptive synergy between cannabinoids and opioids.

Publications

Maltagliati, Anthony J, et al. “Development and Evaluation of a Pre-Clerkship Spiral Curriculum: Data from Three Medical School Classes.”. Med Educ Online, vol. 28, no. 1, Dec. 2023, p. 2167258, https://doi.org/10.1080/10872981.2023.2167258.

Bruhns, Ryan P, et al. “Angiotensin-(1-7) Improves Cognitive Function and Reduces Inflammation in Mice Following Mild Traumatic Brain Injury.”. Front Behav Neurosci, vol. 16, Jan. 2022, p. 903980, https://doi.org/10.3389/fnbeh.2022.903980.

Wahl, Jared R, et al. “Extracellular Alterations in PH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.”. Pharmaceutics, vol. 14, no. 7, Jan. 2022, https://doi.org/10.3390/pharmaceutics14071469.

Ramonett, Aaron, et al. “Regulation of Mitochondrial Fission by GIPC-Mediated Drp1 Retrograde Transport.”. Mol Biol Cell, vol. 33, no. 1, Jan. 2022, p. ar4, https://doi.org/10.1091/mbc.E21-06-0286.

Vizcarra, Velia S, et al. “Targeting 5-HT Receptors and Kv7 Channels in PFC to Attenuate Chronic Neuropathic Pain in Rats Using a Spared Nerve Injury Model.”. Neurosci Lett, vol. 789, Jan. 2022, p. 136864, https://doi.org/10.1016/j.neulet.2022.136864.

Kwak, Eun-A, et al. “β-Spectrin As a Stalk Cell-Intrinsic Regulator of VEGF Signaling.”. Nat Commun, vol. 13, no. 1, Jan. 2022, p. 1326, https://doi.org/10.1038/s41467-022-28933-1.

Levine, Aidan, et al. “An Underrepresented Majority: A Systematic Review Utilizing Allodynic Criteria to Examine the Present Scarcity of Discrete Animal Models for Episodic Migraine.”. Cephalalgia, vol. 41, no. 3, Jan. 2021, pp. 404-16, https://doi.org/10.1177/0333102420966984.

Blawn, Kiera T, et al. “Sex Hormones Regulate NHE1 Functional Expression and Brain Endothelial Proteome to Control Paracellular Integrity of the Blood Endothelial Barrier.”. Brain Res, vol. 1763, Jan. 2021, p. 147448, https://doi.org/10.1016/j.brainres.2021.147448.

Zhang, Hong, et al. “The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area.”. Front Pharmacol, vol. 12, Jan. 2021, p. 632757, https://doi.org/10.3389/fphar.2021.632757.

Smith, Angela F, et al. “Haploinsufficiency of Tau Decreases Survival of the Mouse Model of Niemann-Pick Disease Type C1 But Does Not Alter Tau Phosphorylation.”. J Appl Genet, vol. 61, no. 4, Dec. 2020, pp. 567-70, https://doi.org/10.1007/s13353-020-00572-6.

Doyle, Timothy M, et al. “Activation of Sphingosine-1-Phosphate Receptor Subtype 1 in the Central Nervous System Contributes to Morphine-Induced Hyperalgesia and Antinociceptive Tolerance in Rodents.”. Pain, vol. 161, no. 9, Jan. 2020, pp. 2107-18, https://doi.org/10.1097/j.pain.0000000000001888.

Wiese, Beth M, et al. “Cannabinoid-2 Agonism With AM2301 Mitigates Morphine-Induced Respiratory Depression.”. Cannabis Cannabinoid Res, Jan. 2020, https://doi.org/10.1089/can.2020.0076.

Levine, Aidan, et al. “DAGLα Inhibition As a Non-Invasive and Translational Model of Episodic Headache.”. Front Pharmacol, vol. 11, Jan. 2020, p. 615028, https://doi.org/10.3389/fphar.2020.615028.

Liktor-Busa, Erika, et al. “Functional NHE1 Expression Is Critical to Blood Brain Barrier Integrity and Sumatriptan Blood to Brain Uptake.”. PLoS One, vol. 15, no. 5, Jan. 2020, p. e0227463, https://doi.org/10.1371/journal.pone.0227463.

Zhang, Hong, et al. “Glial Neuroimmune Signaling in Opioid Reward.”. Brain Res Bull, vol. 155, Jan. 2020, pp. 102-11, https://doi.org/10.1016/j.brainresbull.2019.11.012.

Bartlett, Mitchell J, et al. “Highly-Selective µ-Opioid Receptor Antagonism Does Not Block L-DOPA-Induced Dyskinesia in a Rodent Model.”. BMC Res Notes, vol. 13, no. 1, Jan. 2020, p. 149, https://doi.org/10.1186/s13104-020-04994-7.

Johnston, Bree, and Vanderah, Todd W. “Lost in the Haze: The Physician’s Role in Cannabinoid Prescribing and Advising”. Am J Med, vol. 133, no. 1, Jan. 2020, pp. 7-8, https://doi.org/10.1016/j.amjmed.2019.05.049.

Ellingson, Holly M, and Vanderah, Todd W. “Potential Therapeutic Treatments of Cancer-Induced Bone Pain.”. Curr Opin Support Palliat Care, vol. 14, no. 2, Jan. 2020, pp. 107-11, https://doi.org/10.1097/SPC.0000000000000496.

Hay, Meredith, et al. “A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.”. J Pharmacol Exp Ther, vol. 369, no. 1, Jan. 2019, pp. 9-25, https://doi.org/10.1124/jpet.118.254854.

Thompson, Austen L, et al. “Animal Models for the Study of Bone-Derived Pain.”. Methods Mol Biol, vol. 1914, Jan. 2019, pp. 391-07, https://doi.org/10.1007/978-1-4939-8997-3_23.

Moutal, Aubin, et al. “Cdk5-Mediated CRMP2 Phosphorylation Is Necessary and Sufficient for Peripheral Neuropathic Pain.”. Neurobiol Pain, vol. 5, Jan. 2019, https://doi.org/10.1016/j.ynpai.2018.07.003.

Khanna, Rajesh, et al. “Development and Characterization of An Injury-Free Model of Functional Pain in Rats by Exposure to Red Light.”. J Pain, vol. 20, no. 11, Jan. 2019, pp. 1293-06, https://doi.org/10.1016/j.jpain.2019.04.008.

Chen, Zhoumou, et al. “Sphingosine-1-Phosphate Receptor 1 Activation in Astrocytes Contributes to Neuropathic Pain.”. Proc Natl Acad Sci U S A, vol. 116, no. 21, Jan. 2019, pp. 10557-62, https://doi.org/10.1073/pnas.1820466116.

Zhang, Hong, et al. “Peripherally Restricted Cannabinoid 1 Receptor Agonist As a Novel Analgesic in Cancer-Induced Bone Pain.”. Pain, vol. 159, no. 9, Sept. 2018, pp. 1814-23, https://doi.org/10.1097/j.pain.0000000000001278.

Edwards, Katie A, et al. “A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain.”. J Pain, vol. 19, no. 6, Jan. 2018, pp. 612-25, https://doi.org/10.1016/j.jpain.2018.01.002.