Reference
Shah, Nirav, and Lee, Nam Y. “Regulation of Gene Expression and Mitochondrial Dynamics by SMAD”. Mol Cell Oncol, vol. 3, no. 5, Jan. 2016, p. e1204492, https://doi.org/10.1080/23723556.2016.1204492.
Abstract
Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.