Animal Models for the Study of Bone-Derived Pain.

TitleAnimal Models for the Study of Bone-Derived Pain.
Publication TypeJournal Article
Year of Publication2019
AuthorsThompson AL, Largent-Milnes TM, Vanderah TW
JournalMethods Mol Biol
Date Published2019
KeywordsAnimals, Behavior, Animal, Bone and Bones, Bone Neoplasms, Cell Culture Techniques, Cell Line, Tumor, Disease Models, Animal, Female, Fractures, Bone, Humans, Iodoacetic Acid, Male, Mammary Neoplasms, Animal, Mice, Mice, Inbred BALB C, Osteoarthritis, Pain, Pain Measurement, Rats, Sprague-Dawley

Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control. Pain originating in the bone can be caused by many different entities including metastatic and primary neoplasm, fracture, osteoarthritis as well as numerous other metabolic disorders. In this chapter we describe the methods and protocols that currently are accepted and validated for the study of bone pain in models of metastatic cancer, bicortical fracture and osteoarthritis. These animal models provide invaluable information as to the nature of bone pain and give rise to potential new targets for its treatment and management.

Alternate JournalMethods Mol Biol
PubMed ID30729479
PubMed Central IDPMC7008003
Grant ListR01 CA142115 / CA / NCI NIH HHS / United States
Faculty Member Reference: 
Tally Largent-Milnes, PhD
Todd Vanderah, PhD