|Title||Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Zhao L, Mao Z, Schneider LS, Brinton RD|
|Date Published||2011 Oct|
|Keywords||Amyloid beta-Peptides, Animals, Disease Models, Animal, Estrogen Receptor beta, Female, Hair, Hippocampus, Hot Flashes, Humans, Memory Disorders, Memory, Short-Term, Menopause, Mice, Mice, Inbred C57BL, Neuronal Plasticity, Phytoestrogens|
OBJECTIVE: As an alternative to estrogen therapy, the efficacy of an estrogen receptor β-selective phytoestrogenic (phyto-β-SERM) formulation to regulate climacteric symptoms and decline in brain responses associated with ovarian hormone loss in menopause was assessed.
METHODS: A phyto-β-SERM formulation-containing diet was compared with a commercial soy extract diet and a phytoestrogen-free base/control diet in an ovariectomized (OVX) mouse model of human menopause. Two treatment studies were conducted: (1) a 2-month study assessed the effects of experimental diets on tail skin temperature as a model of menopausal hot flashes, and (2) a 9-month study assessed the long-term impact of the diets on overall health, hair thinning/loss, spatial working memory, and associated protein expression in the hippocampus.
RESULTS: The phyto-β-SERM diet prevented OVX-induced menopause-like changes including the rise in skin temperature, hair thinning/loss, deficit in spatial memory function, and reversed OVX-induced decline in the expression of hippocampal proteins involved in neural plasticity and β-amyloid degradation/clearance. The soy extract diet had no effect or exacerbated OVX-induced changes.
CONCLUSIONS: Overall, the phyto-β-SERM diet induced physical and neurological responses comparable with ovary-intact mice, suggesting the therapeutic potential of the phyto-β-SERM formulation for the prevention/alleviation of climacteric symptoms and decline in brain responses induced by ovarian hormone loss, which provides the basis for further work in postmenopausal women.
Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause.
Faculty Member Reference:
Roberta Diaz Brinton, Ph.D