Medication overuse headache.

TitleMedication overuse headache.
Publication TypeJournal Article
Year of Publication2023
AuthorsAshina S, Terwindt GM, Steiner TJ, Lee MJi, Porreca F, Tassorelli C, Schwedt TJ, Jensen RH, Diener H-C, Lipton RB
JournalNat Rev Dis Primers
Date Published2023 Feb 02
KeywordsHeadache, Headache Disorders, Secondary, Humans, Migraine Disorders, Quality of Life

Medication overuse headache (MOH) is a secondary headache disorder attributed to overuse of acute headache medications by a person with an underlying headache disorder, usually migraine or tension-type headache. MOH is common among individuals with 15 or more headache days per month. Although MOH is associated with substantial disability and reductions in quality of life, this condition is often under-recognized. As MOH is both preventable and treatable, it warrants greater attention and awareness. The diagnosis of MOH is based on the history and an unremarkable neurological examination, and is made according to the diagnostic criteria of the International Classification of Headache Disorders third edition (ICHD-3). Pathophysiological mechanisms of MOH include altered descending pain modulation, central sensitization and biobehavioural factors. Treatment of MOH includes the use of headache preventive therapies, but essential to success is eliminating the cause, by reducing the frequency of use of acute headache medication, and perhaps withdrawing the overused medication altogether. Appropriate treatment is usually highly effective, leading to reduced headache burden and acute medication consumption.

Alternate JournalNat Rev Dis Primers
PubMed ID36732518
Faculty Member Reference: 
Frank Porreca, PhD