Frank Porreca, PhD

Associate Department Head, Pharmacology
Professor, Anesthesiology
Professor, Cancer Biology - GIDP
Professor, Pharmacology
Professor, Neuroscience - GIDP

Contact Information

Office: 562
Building: Life Sciences North
Phone: (520) 626-7421

Email: frankp@email.arizona.edu

 

Publications

2017

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics.

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

2016

Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors.

Structure-Activity Relationships of [des-Arg(7)]Dynorphin A Analogues at the κ Opioid Receptor.

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.

(S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.

Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain.

2015

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.

Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.

Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.

Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.

2014

Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord.

Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors.

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord.

2013

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.

Effect of anchoring 4-anilidopiperidines to opioid peptides.

Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.

Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.

2012

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.

Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.

Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.

2011

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.

Development of potent μ and δ opioid agonists with high lipophilicity.

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

2010

Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.

2009

Novel bifunctional peptides as opioid agonists and NK-1 antagonists.

2008

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.

A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.