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2011 |
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. |
Peg Davis, Victor Hruby, Ph.D., Josephine Lai , Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD, Eva Varga, Ph.D. |
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2011 |
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. |
Frank Porreca, PhD, Todd Vanderah, PhD |
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2011 |
Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. |
Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD |
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2011 |
Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. |
Roberta Diaz Brinton, Ph.D |
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2011 |
17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. |
Roberta Diaz Brinton, Ph.D |
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2011 |
Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. |
Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD |
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2010 |
Recently patented and promising ORL-1 ligands: where have we been and where are we going? |
Tally Largent-Milnes, PhD, Todd Vanderah, PhD |
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2010 |
Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. |
Roberta Diaz Brinton, Ph.D |
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2010 |
Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. |
Thomas P Davis, PhD, Jeffrey J. Lochhead, PhD |
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2010 |
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. |
Tally Largent-Milnes, PhD, Patrick W Mantyh, Todd Vanderah, PhD |
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2010 |
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. |
Tally Largent-Milnes, PhD, Todd Vanderah, PhD |
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2010 |
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. |
John M. Streicher, PhD |
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2010 |
Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. |
Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD |
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2010 |
Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. |
John M. Streicher, PhD |
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2010 |
Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. |
Roberta Diaz Brinton, Ph.D |
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2009 |
Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma. |
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2009 |
Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. |
Roberta Diaz Brinton, Ph.D |
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2009 |
Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress. |
Jeffrey J. Lochhead, PhD |
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2009 |
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. |
Roberta Diaz Brinton, Ph.D |
