Publications

Year of Publication Title Faculty Association
2011 Development of potent μ and δ opioid agonists with high lipophilicity. Yeon Sun Lee, Frank Porreca, PhD, Todd Vanderah, PhD
2011 Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Roberta Diaz Brinton, Ph.D
2011 Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Roberta Diaz Brinton, Ph.D
2011 Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD
2011 Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Roberta Diaz Brinton, Ph.D
2011 Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2011 Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. Frank Porreca, PhD, Todd Vanderah, PhD
2011 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2011 Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2010 Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. Thomas P Davis, PhD, Jeffrey J. Lochhead, PhD
2010 Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA. Tally Largent-Milnes, PhD, Todd Vanderah, PhD
2010 Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Roberta Diaz Brinton, Ph.D
2010 Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD
2010 Recently patented and promising ORL-1 ligands: where have we been and where are we going? Tally Largent-Milnes, PhD, Todd Vanderah, PhD
2010 Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. John M. Streicher, PhD
2010 A novel mechanism of acid and bile acid-induced DNA damage involving Na+/H+ exchanger: implication for Barrett's oesophagus. George Watts, Ph.D.
2010 Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Roberta Diaz Brinton, Ph.D
2010 Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. John M. Streicher, PhD
2010 MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. John M. Streicher, PhD
2010 A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. Tally Largent-Milnes, PhD, Patrick W Mantyh, Todd Vanderah, PhD
2010 Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2010 Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Roberta Diaz Brinton, Ph.D
2009 Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study". Roberta Diaz Brinton, Ph.D
2009 Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress. Jeffrey J. Lochhead, PhD
2009 Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2. Roberta Diaz Brinton, Ph.D

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