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2014 |
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. |
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2014 |
Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides. |
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2013 |
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. |
Victor Hruby, Ph.D., Josephine Lai , Ph.D., Tally Largent-Milnes, PhD, Edita Navratilova, Frank Porreca, PhD, Todd Vanderah, PhD |
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2013 |
Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. |
Peg Davis, Victor Hruby, Ph.D., Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD |
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2013 |
Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer's disease. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Effect of anchoring 4-anilidopiperidines to opioid peptides. |
Victor Hruby, Ph.D., Josephine Lai , Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD |
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2013 |
Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. |
Patrick W Mantyh, Tally Largent-Milnes, PhD, Frank Porreca, PhD, Todd Vanderah, PhD |
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2013 |
Development of functionally selective, small molecule agonists at kappa opioid receptors. |
John M. Streicher, PhD |
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2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. |
Victor Hruby, Ph.D., Todd Vanderah, PhD |
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2013 |
Cancer-induced bone pain: Mechanisms and models. |
Todd Vanderah, PhD |
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2013 |
Estrogen, astrocytes and the neuroendocrine control of metabolism. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. |
John M. Streicher, PhD |
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2013 |
Neurosteroids as regenerative agents in the brain: therapeutic implications. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. |
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2013 |
Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. |
Roberta Diaz Brinton, Ph.D |
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2013 |
Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. |
Roberta Diaz Brinton, Ph.D |
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2012 |
17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. |
Roberta Diaz Brinton, Ph.D |
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2012 |
Intranasal delivery of biologics to the central nervous system. |
Jeffrey J. Lochhead, PhD |
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2012 |
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. |
John M. Streicher, PhD |
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2012 |
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. |
Tally Largent-Milnes, PhD, Todd Vanderah, PhD, Eva Varga, Ph.D. |
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2012 |
Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. |
Victor Hruby, Ph.D., Tally Largent-Milnes, PhD, Todd Vanderah, PhD, Eva Varga, Ph.D. |
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2012 |
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. |
Frank Porreca, PhD, Todd Vanderah, PhD |
