Publications

Year of Publication Title Faculty Association
2013 Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. Roberta Diaz Brinton, Ph.D
2013 Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2012 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Roberta Diaz Brinton, Ph.D
2012 Intranasal delivery of biologics to the central nervous system. Jeffrey J. Lochhead, PhD
2012 Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. John M. Streicher, PhD
2012 Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. Tally Largent-Milnes, PhD, William R. Roeske, MD, Todd Vanderah, PhD, Eva Varga, Ph.D.
2012 Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. Victor Hruby, Ph.D., Tally Largent-Milnes, PhD, Todd Vanderah, PhD, Eva Varga, Ph.D.
2012 Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Frank Porreca, PhD, Todd Vanderah, PhD
2012 Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Michael H. Ossipov, Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD
2012 Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. John M. Streicher, PhD
2012 Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. Roberta Diaz Brinton, Ph.D
2012 Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain. Thomas P Davis, PhD, Jeffrey J. Lochhead, PhD, Patrick T Ronaldson, PhD
2012 Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Roberta Diaz Brinton, Ph.D
2012 The matrix protein CCN1/CYR61 is required for α(V)β5-mediated cancer cell migration. George Watts, Ph.D.
2012 Minireview: translational animal models of human menopause: challenges and emerging opportunities. Roberta Diaz Brinton, Ph.D
2012 Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Roberta Diaz Brinton, Ph.D
2012 The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid. George Watts, Ph.D.
2012 A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. Roberta Diaz Brinton, Ph.D
2012 Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Roberta Diaz Brinton, Ph.D
2011 Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Peg Davis, Victor Hruby, Ph.D., Josephine Lai , Ph.D., Frank Porreca, PhD, Todd Vanderah, PhD, Eva Varga, Ph.D.
2011 Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Roberta Diaz Brinton, Ph.D
2011 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Roberta Diaz Brinton, Ph.D
2011 Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Roberta Diaz Brinton, Ph.D
2011 The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Roberta Diaz Brinton, Ph.D
2011 Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Roberta Diaz Brinton, Ph.D

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